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Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 130-138 doi: 10.1007/s11684-017-0555-2
Brown adipose tissue (BAT) plays a fundamental role in maintaining body temperature by producing heat. BAT that had been know to exist only in mammals and the human neonate has received great attention for the treatment of obesity and diabetes due to its important function in energy metabolism, ever since it is recently reported that human adults have functional BAT. In addition, beige adipocytes, brown adipocytes in white adipose tissue (WAT), have also been shown to take part in whole body metabolism. Multiple lines of evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesity and improved insulin sensitivity. Furthermore, many genes involved in BAT activation and/or the recruitment of beige cells have been found, thereby providing new promising strategies for future clinical application of BAT activation to treat obesity and metabolic diseases. This review focuses on recent advances of BAT function in the metabolic aspect and the relationship between BAT and cancer cachexia, a pathological process accompanied with decreased body weight and increased energy expenditure in cancer patients. The underlying possible mechanisms to reduce BAT mass and its activity in the elderly are also discussed.
关键词: brown adipose tissue beige adipocyte anti-obesity anti-diabetes cancer cachexia aging
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 229-234 doi: 10.1007/s11684-010-0028-3
关键词: steroid receptor coactivator-3 white adipose tissue brown adipose tissue obesity adipocytes energy expenditure
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid
《医学前沿(英文)》 2021年 第15卷 第6期 页码 887-902 doi: 10.1007/s11684-021-0879-9
关键词: microRNAs monocarboxylate transporter 1 motor training subarachnoid hemorrhage white matter injury
Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 216-223 doi: 10.1007/s11705-012-1289-y
关键词: recombinant protein polyclonal antibody label-free biosensor impedance white spot syndrome virus (WSSV)
Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG
《农业科学与工程前沿(英文)》 2014年 第1卷 第4期 页码 299-306 doi: 10.15302/J-FASE-2014040
关键词: Silky Fowl White Leghorn melanoblast migration gene expression
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Progress and perspectives of neural tissue engineering
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 401-411 doi: 10.1007/s11684-015-0415-x
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 6-10 doi: 10.1007/s11684-007-0002-x
关键词: available observable neuroregeneration protection function reconstruction
Decellularized extracellular matrix mediates tissue construction and regeneration
《医学前沿(英文)》 2022年 第16卷 第1期 页码 56-82 doi: 10.1007/s11684-021-0900-3
关键词: decellularized extracellular matrix 3D culture organoids tissue repair
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 112-116 doi: 10.1007/s11684-010-0016-7
关键词: cervical cancer radical surgery peritoneum subcutaneous tissue
Primary cilia in hard tissue development and diseases
《医学前沿(英文)》 2021年 第15卷 第5期 页码 657-678 doi: 10.1007/s11684-021-0829-6
关键词: primary cilia bone mechanical sensing hard tissue cilium-related bone disease tooth
Min-Ho CHEY, Jae-Ung KIM
《结构与土木工程前沿(英文)》 2012年 第6卷 第3期 页码 267-280 doi: 10.1007/s11709-012-0170-x
关键词: tuned mass damper parametric optimization passive control white noise earthquake excitation
Stem cell niches and endogenous electric fields in tissue repair
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 40-44 doi: 10.1007/s11684-011-0108-z
Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
Microorganism-derived biological macromolecules for tissue engineering
《医学前沿(英文)》 2022年 第16卷 第3期 页码 358-377 doi: 10.1007/s11684-021-0903-0
关键词: biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate
Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 415-420 doi: 10.1007/s11684-009-0072-z
关键词: tissue inhibitor of metalloproteinase-3 intervertebral disc rabbit gene therapy
标题 作者 时间 类型 操作
Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure
Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,
期刊论文
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid
期刊论文
Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv
Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT
期刊论文
A microarray study of altered gene expression during melanoblasts migration in normal pigmented White
Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG
期刊论文
Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
期刊论文
control of structural responses using an optimal passive tuned mass damper under stationary Gaussian white
Min-Ho CHEY, Jae-Ung KIM
期刊论文